Original Article
Pak J Nucl Med. 2018; 8(1): 3-7

Is intermittent pneumatic compression (IPC) an appropriate method for increasing 99m Tc-MDP uptake in bone scan?

Authors: Susan Shafiei, Narjess Ayati, Hamideh Sadra, Gholam Hosein Kazemzadeh, Samira Zare namdar, Baharak Attar, Seyed Rasoul Zakavi.

View PDF DOI: 10.24911/PJNMed.175-1529737505

Abstract

Background: Currently, intermittent pneumatic compression (IPC) is a standard method of lymphedema treatment. Recently, the effect of this modality in patients with limb arterial insufficiency has been researched. It has been suggested that the arterial inflow to the long bones is also increased by IPC. The purpose of this paper is to assess the effect of lower limb IPC on the blood flow as well as delayed bone uptake. Methods: In this prospective study, we evaluated 30 patients who were referred for whole body bone scan to our Nuclear Medicine Department. All the patients had been examined by a vascular surgeon for ruling out any peripheral neuropathy, vasculopathy or ulcer in the lower limbs. Also, all the patients were questioned about hypertension, diabetes mellitus, and other chronic diseases with peripheral complications. Following 925MBq of 99mTc-methylenediphosphonate (MDP) injection, perfusion and blood pool images of both legs as well as static delayed images were done after the completion of IPC. Results: Thirty patients (10 male) with the age range of 3084 years (mean = 53.4) were included. Radiotracer uptake in flow and blood pool images in the compressed limb was significantly more than the contralateral limb, however, on delayed images, no significant difference was noted between two limbs. Conclusion: Although IPC can significantly increase blood flow of the compressed limb, MDP uptake on the delayed images was not increased. According to this study, IPC may not be useful as a technique to increase releasing chemotherapy drugs or other substances to the bone and promoting bone growth.

Keywords:   Intermittent pneumatic compression, IPC, bone scan, MDP uptake, vascular flow.


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Is intermittent pneumatic compression (IPC) an appropriate method for increasing 99m Tc-MDP uptake in bone scan?


Authors
Susan Shafiei
Nuclear Medicine Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
PubMed articlesGoogle scholar articles

Narjess Ayati
Nuclear Medicine Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
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Hamideh Sadra
Nuclear Medicine Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
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Gholam Hosein Kazemzadeh
Vascular and Endovascular Surgery Research Center. Mashhad University of Medical Sciences
PubMed articlesGoogle scholar articles

Samira Zare namdar
Nuclear Medicine Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
PubMed articlesGoogle scholar articles

Baharak Attar
Nuclear Medicine Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
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Seyed Rasoul Zakavi
Nuclear Medicine Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
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Correspondence to:
Narjess Ayati. Narjess Ayati, Nuclear Medicine Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; ayatin@mums.ac.ir

Publication history
Received 23 Jun 2018
Revised 23 Sep 2018
Accepted 23 Apr 2019
Published online 08 Oct 2019
Published in print 10 Dec 2019
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How to cite this article

Pubmed Style

Susan Shafiei, Narjess Ayati, Hamideh Sadra, Gholam Hosein Kazemzadeh, Samira Zare namdar, Baharak Attar, Seyed Rasoul Zakavi. Is intermittent pneumatic compression (IPC) an appropriate method for increasing 99m Tc-MDP uptake in bone scan?. Pak J Nucl Med. 2018; 8(1): 3-7. doi:10.24911/PJNMed.175-1529737505


Web Style

Susan Shafiei, Narjess Ayati, Hamideh Sadra, Gholam Hosein Kazemzadeh, Samira Zare namdar, Baharak Attar, Seyed Rasoul Zakavi. Is intermittent pneumatic compression (IPC) an appropriate method for increasing 99m Tc-MDP uptake in bone scan?. http://www.pjnmed.com/?mno=302526 [Access: April 08, 2020]. doi:10.24911/PJNMed.175-1529737505


AMA (American Medical Association) Style

Susan Shafiei, Narjess Ayati, Hamideh Sadra, Gholam Hosein Kazemzadeh, Samira Zare namdar, Baharak Attar, Seyed Rasoul Zakavi. Is intermittent pneumatic compression (IPC) an appropriate method for increasing 99m Tc-MDP uptake in bone scan?. Pak J Nucl Med. 2018; 8(1): 3-7. doi:10.24911/PJNMed.175-1529737505


Vancouver/ICMJE Style

Susan Shafiei, Narjess Ayati, Hamideh Sadra, Gholam Hosein Kazemzadeh, Samira Zare namdar, Baharak Attar, Seyed Rasoul Zakavi. Is intermittent pneumatic compression (IPC) an appropriate method for increasing 99m Tc-MDP uptake in bone scan?. Pak J Nucl Med. (2018), [cited April 08, 2020]; 8(1): 3-7. doi:10.24911/PJNMed.175-1529737505


Harvard Style

Susan Shafiei, Narjess Ayati, Hamideh Sadra, Gholam Hosein Kazemzadeh, Samira Zare namdar, Baharak Attar, Seyed Rasoul Zakavi (2018) Is intermittent pneumatic compression (IPC) an appropriate method for increasing 99m Tc-MDP uptake in bone scan?. Pak J Nucl Med, 8 (1), 3-7. doi:10.24911/PJNMed.175-1529737505


Turabian Style

Susan Shafiei, Narjess Ayati, Hamideh Sadra, Gholam Hosein Kazemzadeh, Samira Zare namdar, Baharak Attar, Seyed Rasoul Zakavi. 2018. Is intermittent pneumatic compression (IPC) an appropriate method for increasing 99m Tc-MDP uptake in bone scan?. Pakistan Journal of Nuclear Medicine, 8 (1), 3-7. doi:10.24911/PJNMed.175-1529737505


Chicago Style

Susan Shafiei, Narjess Ayati, Hamideh Sadra, Gholam Hosein Kazemzadeh, Samira Zare namdar, Baharak Attar, Seyed Rasoul Zakavi. "Is intermittent pneumatic compression (IPC) an appropriate method for increasing 99m Tc-MDP uptake in bone scan?." Pakistan Journal of Nuclear Medicine 8 (2018), 3-7. doi:10.24911/PJNMed.175-1529737505


MLA (The Modern Language Association) Style

Susan Shafiei, Narjess Ayati, Hamideh Sadra, Gholam Hosein Kazemzadeh, Samira Zare namdar, Baharak Attar, Seyed Rasoul Zakavi. "Is intermittent pneumatic compression (IPC) an appropriate method for increasing 99m Tc-MDP uptake in bone scan?." Pakistan Journal of Nuclear Medicine 8.1 (2018), 3-7. Print. doi:10.24911/PJNMed.175-1529737505


APA (American Psychological Association) Style

Susan Shafiei, Narjess Ayati, Hamideh Sadra, Gholam Hosein Kazemzadeh, Samira Zare namdar, Baharak Attar, Seyed Rasoul Zakavi (2018) Is intermittent pneumatic compression (IPC) an appropriate method for increasing 99m Tc-MDP uptake in bone scan?. Pakistan Journal of Nuclear Medicine, 8 (1), 3-7. doi:10.24911/PJNMed.175-1529737505


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