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Online Published: 28 Dec 2025
 


Comparative study of functional values related renal calculated with 99mTc-DTPA and 99mTc-DMSA on 42 patients in the nuclear medicine department of the hospital général Idrissa Pouye

Mamoudou Salif Djigo, Diop Ousseynou, Ki Thierry, Thiaw Gora, Adji Thioro Boye, El Hadj Amadou Lamine Bathily, Ndong Boucar.


Abstract
Background: The assessment of renal function is a major challenge in nuclear medicine, in particular for the diagnosis and followup of kidney’s pathologies. The technical scans using 99mTc-DMSA and the 99mTc-DTPA, are widely used to measure relative renal function (RRF). The 99mTc-DMSA provides a static analysis of the renal parenchyma and the detection of scars. The 99mTc-DTPA offers a dynamic approach in assessing the glomerular filtration rate (GFR). This study aims to compare these two methods in order to determine their degree of correlation and their possible interchangeability.
Methods : The study was conducted in the Nuclear Medicine Department of the Hospital General Idrissa Pouye in Dakar, on a sample of 42 patients whose average age was 3.38 years.
Results: The correlation analysis and bivariate analysis revealed a significant positive correlation (r = 0.996, p < 0.001) between the RRF calculated by the two methods. Following the diagnosis of patients, the ANOVA test showed no significant difference between the RRF calculated for the kidneys (left and right). The Bland-Altman plot analysis indicated a mean difference close to zero between the two methods, estimated at −0.43 for the right kidney and 0.43 for the left kidney. The limits of agreement range from −13.02 to 12.17 for the right kidney and −12.15 to 13.01 for the left kidney.
Conclusion: According to the results obtained in this study, the methods of scintigraphy using 99mTc-DMSA and the 99mTc-DTPA provide values of relative renal function on the (RRF) is almost identical, thus making them to be calculated systematically with the two techniques are not essential. The 99mTc-DMSA could be the choice of first-line for the evaluation of the RRF. However, if a measure of the GFR and an analysis of the curve of the rénogramme are necessary, the 99mTc-DTPA is a preferred option.

Key words: Relative renal function, 99mTc-DMSA, 99mTc-DTPA, Bland-Altman plot.


 
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How to Cite this Article
Pubmed Style

Djigo MS, Ousseynou D, Thierry K, Gora T, Boye AT, Bathily EHAL, Boucar N. Comparative study of functional values related renal calculated with 99mTc-DTPA and 99mTc-DMSA on 42 patients in the nuclear medicine department of the hospital général Idrissa Pouye. Pak J Nucl Med. 2025; 15(1): 17-24. doi:10.24911/PJNMed.175-1752011403

Web Style

Djigo MS, Ousseynou D, Thierry K, Gora T, Boye AT, Bathily EHAL, Boucar N. Comparative study of functional values related renal calculated with 99mTc-DTPA and 99mTc-DMSA on 42 patients in the nuclear medicine department of the hospital général Idrissa Pouye. https://www.pjnmed.com/?mno=269830 [Access: January 11, 2026]. doi:10.24911/PJNMed.175-1752011403

AMA (American Medical Association) Style

Djigo MS, Ousseynou D, Thierry K, Gora T, Boye AT, Bathily EHAL, Boucar N. Comparative study of functional values related renal calculated with 99mTc-DTPA and 99mTc-DMSA on 42 patients in the nuclear medicine department of the hospital général Idrissa Pouye. Pak J Nucl Med. 2025; 15(1): 17-24. doi:10.24911/PJNMed.175-1752011403


Vancouver/ICMJE Style

Djigo MS, Ousseynou D, Thierry K, Gora T, Boye AT, Bathily EHAL, Boucar N. Comparative study of functional values related renal calculated with 99mTc-DTPA and 99mTc-DMSA on 42 patients in the nuclear medicine department of the hospital général Idrissa Pouye. Pak J Nucl Med. (2025), [cited January 11, 2026]; 15(1): 17-24. doi:10.24911/PJNMed.175-1752011403


Harvard Style

Djigo, M. S., Ousseynou, . D., Thierry, . K., Gora, . T., Boye, . A. T., Bathily, . E. H. A. L. & Boucar, . N. (2025) Comparative study of functional values related renal calculated with 99mTc-DTPA and 99mTc-DMSA on 42 patients in the nuclear medicine department of the hospital général Idrissa Pouye. Pak J Nucl Med, 15 (1), 17-24. doi:10.24911/PJNMed.175-1752011403


Turabian Style

Djigo, Mamoudou Salif, Diop Ousseynou, Ki Thierry, Thiaw Gora, Adji Thioro Boye, El Hadj Amadou Lamine Bathily, and Ndong Boucar. 2025. Comparative study of functional values related renal calculated with 99mTc-DTPA and 99mTc-DMSA on 42 patients in the nuclear medicine department of the hospital général Idrissa Pouye. Pakistan Journal of Nuclear Medicine, 15 (1), 17-24. doi:10.24911/PJNMed.175-1752011403


Chicago Style

Djigo, Mamoudou Salif, Diop Ousseynou, Ki Thierry, Thiaw Gora, Adji Thioro Boye, El Hadj Amadou Lamine Bathily, and Ndong Boucar. "Comparative study of functional values related renal calculated with 99mTc-DTPA and 99mTc-DMSA on 42 patients in the nuclear medicine department of the hospital général Idrissa Pouye." Pakistan Journal of Nuclear Medicine 15 (2025), 17-24. doi:10.24911/PJNMed.175-1752011403


MLA (The Modern Language Association) Style

Djigo, Mamoudou Salif, Diop Ousseynou, Ki Thierry, Thiaw Gora, Adji Thioro Boye, El Hadj Amadou Lamine Bathily, and Ndong Boucar. "Comparative study of functional values related renal calculated with 99mTc-DTPA and 99mTc-DMSA on 42 patients in the nuclear medicine department of the hospital général Idrissa Pouye." Pakistan Journal of Nuclear Medicine 15.1 (2025), 17-24. Print. doi:10.24911/PJNMed.175-1752011403


APA (American Psychological Association) Style

Djigo, M. S., Ousseynou, . D., Thierry, . K., Gora, . T., Boye, . A. T., Bathily, . E. H. A. L. & Boucar, . N. (2025) Comparative study of functional values related renal calculated with 99mTc-DTPA and 99mTc-DMSA on 42 patients in the nuclear medicine department of the hospital général Idrissa Pouye. Pakistan Journal of Nuclear Medicine, 15 (1), 17-24. doi:10.24911/PJNMed.175-1752011403




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