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Commentary
Online Published: 04 Sep 2026
 


Modern surgical approaches in differentiated thyroid cancer: from ATA 2015 to ATA 2025

Muhammad Naeem, Warda Ahmad, Tania Jabbar, Maria Asghar.


Abstract
The transition from the American Thyroid Association (ATA) 2015 to 2025 Guidelines for differentiated thyroid cancer reflects a paradigm shift toward personalized, risk-adapted surgical strategies. Recent evidence supports thyroid lobectomy as an adequate treatment for selected low-risk patients with small, intrathyroidal tumors, offering comparable oncologic outcomes to total thyroidectomy, with reduced complication rates and improved quality of life. Conversely, total thyroidectomy remains essential in high-risk disease, including large tumors, extrathyroidal extension, nodal metastases, or aggressive histological variants, and when radioactive iodine therapy is indicated. The ATA 2025 Guidelines further refine intermediate-risk stratification and incorporate selective use of molecular profiling, including mutations such as BRAF and TERT, to guide surgical extent. Lymph node management emphasizes therapeutic rather than prophylactic dissection to minimize morbidity. Overall, modern surgical approaches prioritize oncologic safety while reducing treatment-related complications, reflecting an evolving trend toward individualized patient-centered care.

Key words: American Thyroid Association, Differentiated thyroid cancer; Molecular profiling, Lobectomy, Surgical approaches, Thyroidectomy


 
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How to Cite this Article
Pubmed Style

Naeem M, Ahmad W, Jabbar T, Asghar M. Modern surgical approaches in differentiated thyroid cancer: from ATA 2015 to ATA 2025. Pak J Nucl Med. 2026; 16(1): 14-16. doi:10.24911/PJNMed.175-1775818745

Web Style

Naeem M, Ahmad W, Jabbar T, Asghar M. Modern surgical approaches in differentiated thyroid cancer: from ATA 2015 to ATA 2025. https://www.pjnmed.com/?mno=317025 [Access: September 19, 2026]. doi:10.24911/PJNMed.175-1775818745

AMA (American Medical Association) Style

Naeem M, Ahmad W, Jabbar T, Asghar M. Modern surgical approaches in differentiated thyroid cancer: from ATA 2015 to ATA 2025. Pak J Nucl Med. 2026; 16(1): 14-16. doi:10.24911/PJNMed.175-1775818745


Vancouver/ICMJE Style

Naeem M, Ahmad W, Jabbar T, Asghar M. Modern surgical approaches in differentiated thyroid cancer: from ATA 2015 to ATA 2025. Pak J Nucl Med. (2026), [cited September 19, 2026]; 16(1): 14-16. doi:10.24911/PJNMed.175-1775818745


Harvard Style

Naeem, M., Ahmad, . W., Jabbar, . T. & Asghar, . M. (2026) Modern surgical approaches in differentiated thyroid cancer: from ATA 2015 to ATA 2025. Pak J Nucl Med, 16 (1), 14-16. doi:10.24911/PJNMed.175-1775818745


Turabian Style

Naeem, Muhammad, Warda Ahmad, Tania Jabbar, and Maria Asghar. 2026. Modern surgical approaches in differentiated thyroid cancer: from ATA 2015 to ATA 2025. Pakistan Journal of Nuclear Medicine, 16 (1), 14-16. doi:10.24911/PJNMed.175-1775818745


Chicago Style

Naeem, Muhammad, Warda Ahmad, Tania Jabbar, and Maria Asghar. "Modern surgical approaches in differentiated thyroid cancer: from ATA 2015 to ATA 2025." Pakistan Journal of Nuclear Medicine 16 (2026), 14-16. doi:10.24911/PJNMed.175-1775818745


MLA (The Modern Language Association) Style

Naeem, Muhammad, Warda Ahmad, Tania Jabbar, and Maria Asghar. "Modern surgical approaches in differentiated thyroid cancer: from ATA 2015 to ATA 2025." Pakistan Journal of Nuclear Medicine 16.1 (2026), 14-16. Print. doi:10.24911/PJNMed.175-1775818745


APA (American Psychological Association) Style

Naeem, M., Ahmad, . W., Jabbar, . T. & Asghar, . M. (2026) Modern surgical approaches in differentiated thyroid cancer: from ATA 2015 to ATA 2025. Pakistan Journal of Nuclear Medicine, 16 (1), 14-16. doi:10.24911/PJNMed.175-1775818745




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