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2023, Vol: 13, Issue: 1
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Online Publishing Date:
11 / 12 / 2023

 


Genetic Perspectives on Prostate Cancer: Unveiling the Impact on Targeted Radionuclide Therapies

Hamid Shabbir, Muhammad Babar Imran, Nayyar Rubab.


Abstract
Prostate cancer (PCa) is the 2nd most common malignancy in males and the leading cause of cancer-related deaths among men. In recent years, novel therapies have emerged for metastatic castration-resistant prostate cancer (mCRPC) including immunotherapy, androgen-receptor signaling inhibitors, and radio-nuclide therapies. DNA Damage Repair (DDR) genes are frequently mutated in advance PCa and are useful biomarkers for targeted therapy such as poly-ADP ribose polymerase (PARP) inhibitors. DDR gene defects may affect tissue radio-sensitivity and could serve as biomarkers for therapy with alpha and beta-emitting radionuclides. Preliminary clinical reports suggest a potential trend toward longer survival in DDR+ subjects when treated with α-emitters, however, survival benefit was not significant in patients treated with β-emitting radionuclides. A comprehensive study regarding the impact of DDR genes in prostate cancer patients treated with alpha emitters is vital.

Key words: Prostate Cancer, Radionuclide, Genomics, Therapy, DDR.


 
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How to Cite this Article
Pubmed Style

Shabbir H, Imran MB, Rubab N. Genetic Perspectives on Prostate Cancer: Unveiling the Impact on Targeted Radionuclide Therapies. Pak J Nucl Med. 2023; 13(1): 13-16. doi:10.24911/PJNMed.175-1696399353

Web Style

Shabbir H, Imran MB, Rubab N. Genetic Perspectives on Prostate Cancer: Unveiling the Impact on Targeted Radionuclide Therapies. https://www.pjnmed.com/?mno=171966 [Access: February 27, 2024]. doi:10.24911/PJNMed.175-1696399353

AMA (American Medical Association) Style

Shabbir H, Imran MB, Rubab N. Genetic Perspectives on Prostate Cancer: Unveiling the Impact on Targeted Radionuclide Therapies. Pak J Nucl Med. 2023; 13(1): 13-16. doi:10.24911/PJNMed.175-1696399353


Vancouver/ICMJE Style

Shabbir H, Imran MB, Rubab N. Genetic Perspectives on Prostate Cancer: Unveiling the Impact on Targeted Radionuclide Therapies. Pak J Nucl Med. (2023), [cited February 27, 2024]; 13(1): 13-16. doi:10.24911/PJNMed.175-1696399353


Harvard Style

Shabbir, H., Imran, . M. B. & Rubab, . N. (2023) Genetic Perspectives on Prostate Cancer: Unveiling the Impact on Targeted Radionuclide Therapies. Pak J Nucl Med, 13 (1), 13-16. doi:10.24911/PJNMed.175-1696399353


Turabian Style

Shabbir, Hamid, Muhammad Babar Imran, and Nayyar Rubab. 2023. Genetic Perspectives on Prostate Cancer: Unveiling the Impact on Targeted Radionuclide Therapies. Pakistan Journal of Nuclear Medicine, 13 (1), 13-16. doi:10.24911/PJNMed.175-1696399353


Chicago Style

Shabbir, Hamid, Muhammad Babar Imran, and Nayyar Rubab. "Genetic Perspectives on Prostate Cancer: Unveiling the Impact on Targeted Radionuclide Therapies." Pakistan Journal of Nuclear Medicine 13 (2023), 13-16. doi:10.24911/PJNMed.175-1696399353


MLA (The Modern Language Association) Style

Shabbir, Hamid, Muhammad Babar Imran, and Nayyar Rubab. "Genetic Perspectives on Prostate Cancer: Unveiling the Impact on Targeted Radionuclide Therapies." Pakistan Journal of Nuclear Medicine 13.1 (2023), 13-16. Print. doi:10.24911/PJNMed.175-1696399353


APA (American Psychological Association) Style

Shabbir, H., Imran, . M. B. & Rubab, . N. (2023) Genetic Perspectives on Prostate Cancer: Unveiling the Impact on Targeted Radionuclide Therapies. Pakistan Journal of Nuclear Medicine, 13 (1), 13-16. doi:10.24911/PJNMed.175-1696399353




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