E-ISSN 2305-1620 | ISSN 2221-0288
 
2023, Vol: 13, Issue: 1
13 / 1Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles
Required files to be uploaded

Title page (Sample)

Original Article

Online Publishing Date:
14 / 04 / 2020

 


Skeletal metastatic distribution of HCC on 99mTc-MDP bone scan with a unique feature of soft tissue component

Muhammad Iqbal, Muhammad Naeem, Muhammad Babar Imran, Muhammad Shahzad Afzal, Owais Bin Qadeer Gill.


Abstract
Background: Hepatocellular carcinoma (HCC) is the 5th leading cancer which metastasizes to bones in 3%-20% cases. The routes of metastasis from HCC include hematogenous, lymphatic, or direct invasion/dissemination/ seedlings into the surrounding cavities. The 99mTc-methylene diphosphonate (MDP) bone scintigraphy is a sensitive imaging technique for early detection of skeletal metastasis.
Methods: Bone scans of 220 patients with HCC from 1st January 2012 to 31st December 2017, referred to nuclear medicine department for evaluation of skeletal metastasis, were analyzed. About 70% presented with backache followed by rib cage pains (25%).
Results: Out of total 220 patients, 40 patients (18%) had skeletal metastasis on 99mTc-MDP bone scans, with solitary to multiple metastasis ratio was 1:9. Vertebrae were the most common site of metastasis (27/40 patients, 67%). Most striking characteristic of bone metastasis of HCC was the presence of soft tissue element in vertebral metastasis. This soft tissue element is responsible for compression symptoms in these patients. These soft tissue components were poorly outlined on routine planner bone scans due to poor99mTc-MDP uptake but were better diagnosed with Single Photon Emission Tomography / Computed Tomography.‑
Conclusion: Skeletal metastatic distribution of HCC follows an unusual pattern on 99mTc-MDP bone scan with a unique feature of soft tissue component, especially in larger lesions involving spine. During radiotherapy planning, these soft tissue lesions must be included in the field of irradiation to improve post radiotherapy outcome and may play a vital role in determining progression or regression of the disease.

Key words: Hepatocellular carcinoma (HCC), Bone metastasis, Soft tissue component, 99mTc-methylene diphosphonate (MDP) bone scintigraphy, 99mTc-MDP SPECT/CT.


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Muhammad Iqbal
Articles by Muhammad Naeem
Articles by Muhammad Babar Imran
Articles by Muhammad Shahzad Afzal
Articles by Owais Bin Qadeer Gill
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Iqbal M, Naeem M, Imran MB, Afzal MS, Gill OBQ. Skeletal metastatic distribution of HCC on 99mTc-MDP bone scan with a unique feature of soft tissue component. Pak J Nucl Med. 2019; 9(1): 17-20. doi:10.24911/PJNMed.175-1577091442

Web Style

Iqbal M, Naeem M, Imran MB, Afzal MS, Gill OBQ. Skeletal metastatic distribution of HCC on 99mTc-MDP bone scan with a unique feature of soft tissue component. https://www.pjnmed.com/?mno=79060 [Access: February 28, 2024]. doi:10.24911/PJNMed.175-1577091442

AMA (American Medical Association) Style

Iqbal M, Naeem M, Imran MB, Afzal MS, Gill OBQ. Skeletal metastatic distribution of HCC on 99mTc-MDP bone scan with a unique feature of soft tissue component. Pak J Nucl Med. 2019; 9(1): 17-20. doi:10.24911/PJNMed.175-1577091442


Vancouver/ICMJE Style

Iqbal M, Naeem M, Imran MB, Afzal MS, Gill OBQ. Skeletal metastatic distribution of HCC on 99mTc-MDP bone scan with a unique feature of soft tissue component. Pak J Nucl Med. (2019), [cited February 28, 2024]; 9(1): 17-20. doi:10.24911/PJNMed.175-1577091442


Harvard Style

Iqbal, M., Naeem, . M., Imran, . M. B., Afzal, . M. S. & Gill, . O. B. Q. (2019) Skeletal metastatic distribution of HCC on 99mTc-MDP bone scan with a unique feature of soft tissue component. Pak J Nucl Med, 9 (1), 17-20. doi:10.24911/PJNMed.175-1577091442


Turabian Style

Iqbal, Muhammad, Muhammad Naeem, Muhammad Babar Imran, Muhammad Shahzad Afzal, and Owais Bin Qadeer Gill. 2019. Skeletal metastatic distribution of HCC on 99mTc-MDP bone scan with a unique feature of soft tissue component. Pakistan Journal of Nuclear Medicine, 9 (1), 17-20. doi:10.24911/PJNMed.175-1577091442


Chicago Style

Iqbal, Muhammad, Muhammad Naeem, Muhammad Babar Imran, Muhammad Shahzad Afzal, and Owais Bin Qadeer Gill. "Skeletal metastatic distribution of HCC on 99mTc-MDP bone scan with a unique feature of soft tissue component." Pakistan Journal of Nuclear Medicine 9 (2019), 17-20. doi:10.24911/PJNMed.175-1577091442


MLA (The Modern Language Association) Style

Iqbal, Muhammad, Muhammad Naeem, Muhammad Babar Imran, Muhammad Shahzad Afzal, and Owais Bin Qadeer Gill. "Skeletal metastatic distribution of HCC on 99mTc-MDP bone scan with a unique feature of soft tissue component." Pakistan Journal of Nuclear Medicine 9.1 (2019), 17-20. Print. doi:10.24911/PJNMed.175-1577091442


APA (American Psychological Association) Style

Iqbal, M., Naeem, . M., Imran, . M. B., Afzal, . M. S. & Gill, . O. B. Q. (2019) Skeletal metastatic distribution of HCC on 99mTc-MDP bone scan with a unique feature of soft tissue component. Pakistan Journal of Nuclear Medicine, 9 (1), 17-20. doi:10.24911/PJNMed.175-1577091442




Most Viewed Articles
Most Accessed Articles

  • Determination of the optimum filter for 99mTc SPECT breast imaging using a wire mesh collimator
    Xianling Dong, M I Saripan, R Mahmud, S Mashohor, Aihui Wang
    Pak J Nucl Med. 2017; 7(1): 9-15
    » Abstract » doi: 10.24911/PJNMed.7.2

  • Behaviour of wedges for different field sizes and depths
    Sajjad Ahmed Memon, Naeem Ahmed Laghari, Fayaz Hussain Mangi
    Pak J Nucl Med. 2017; 7(1): 20-27
    » Abstract » doi: 10.24911/PJNMed.7.4

  • Pre-operative cardiac risk stratification for noncardiac surgery in cancer patients using myocardial perfusion scintigraphy
    Iqbal Munir, Amrah Javaid, Khalid Nawaz, Mohammed Hathaf Al-Rowaily, Muaadh Abdualrehman Al-Asbahi
    Pak J Nucl Med. 2017; 7(1): 28-33
    » Abstract » doi: 10.24911/PJNMed.7.5

  • Clinical characteristics and long-term outcome of patients with differentiated carcinoma of thyroid with bone metastases: a retrospective study
    Sadaf Tufail Butt, Shazia Fatima, Noreen Marwat, Kahkashan Mir, Ayesha Ammar, Mohammad Faheem
    Pak J Nucl Med. 2017; 7(1): 34-37
    » Abstract » doi: 10.24911/PJNMed.7.6

  • A brief review of targetted radionuclide therapies
    Mohammed Hathaf Al-Rowaily, Daniele Dondi, MarcoChinol, Iqbal Munir, Muaadh Abdualrehman Alasbahi
    Pak J Nucl Med. 2017; 7(1): 4-8
    » Abstract » doi: 10.24911/PJNMed.7.1

    •
    Most Downloaded
    Top Downloaded Articles

  • Behaviour of wedges for different field sizes and depths
    Sajjad Ahmed Memon, Naeem Ahmed Laghari, Fayaz Hussain Mangi
    Pak J Nucl Med. 2017; 7(1): 20-27
    » Abstract » doi: 10.24911/PJNMed.7.4

  • Determination of the optimum filter for 99mTc SPECT breast imaging using a wire mesh collimator
    Xianling Dong, M I Saripan, R Mahmud, S Mashohor, Aihui Wang
    Pak J Nucl Med. 2017; 7(1): 9-15
    » Abstract » doi: 10.24911/PJNMed.7.2

  • Characterization of SIEMENS Symbia T SPECT camera in Monte Carlo simulation environment
    Xianling Dong, Mahmud Iqbal Saripan, Rozi Mahmud, Syamsiah Mashohor, Aihui Wang,
    Pak J Nucl Med. 2018; 8(1): 18-26
    » Abstract » doi: 10.24911/PJNMed.175-1540569779

  • A historic review of the discovery of the medical uses of radioiodine
    Barbara Hertz, Pushan Bharadwaj, Bennett Greenspan
    Pak J Nucl Med. 2020; 10(1): 60-63
    » Abstract » doi: 10.24911/PJNMed.175-1582813482

  • A brief review of targetted radionuclide therapies
    Mohammed Hathaf Al-Rowaily, Daniele Dondi, MarcoChinol, Iqbal Munir, Muaadh Abdualrehman Alasbahi
    Pak J Nucl Med. 2017; 7(1): 4-8
    » Abstract » doi: 10.24911/PJNMed.7.1

    •
    Most Cited Articles
    Most Cited Articles

    About Pakistan Journal of Nuclear Medicine

    The Pakistan Journal of Nuclear Medicine (PJNM) is the official journal of the Pakistan Society of Nuclear Medicine and the first nuclear medicine journal ... Read more.



    For best results, please use Internet Explorer or Google Chrome.

    Contact Information

    Address: Pakistan Journal of Nuclear Medicine (PJNM), Room # D-115, D-Block, Department of Medical Sciences, Pakistan Institute of Engineering and Applied Sciences (PIEAS), Islamabad, 45650, Pakistan.

    Email: pjnm@pieas.edu.pk, Phone: +92 51 9248706, Fax: +92 51 9248600

    Title Owner: Pakistan Society of Nuclear Medicine

    https://psnmed.com/

    Society Email: secretary@psnmed.com

    Address: Institute of Nuclear Medicine & Oncology (INMOL), New Campus Road, Lahore, Pakistan.

    Contact the publisher:

    contact@discoverpublish.com

    https://discoverpublish.com/ 

    Address: Discover STM Publishing Ltd, 82 Leslie's Arch, Old Quarter, Ballincollig, Cork, P31 RY62, Ireland.

    Hours:  M-F: 8:30am - 5:30pm

    Contact Emails:

    Journal Editorial Office: contact@pjnmed.com

    Billing Support:  contact@discoverpublish.com

    Technical Support: anastasiia.pavlenco@sofiafields.com - https://sofiafields.com/ 


     
    POLICIES & JOURNAL LINKS
    Author Login
    Reviewer Login
    About Publisher
    Advertising Policy
    Author's Rights and Obligations
    Conflict of Interest Policy
    Copyright Information
    Digital Archiving & Preservation Policies
    Editorial Policies
    Peer Review Policy
    Editorial & Peer Review Process
    License Information
    Open Access Policy
    Plagiarism Policy
    Privacy Policy
    Protection of Research Participants (Statement On Human And Animal Rights)
    Publication Ethics and Publication Malpractice Statement
    Corrections, Retractions & Expressions of Concern
    Self-Archiving Policies
    Statement of Informed Consent
    Terms of Use