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Case Report
Online Published: 30 Dec 2025
 


Detection of soft tissue metastasis in a Grade-1 Neuroendocrine Tumor: a case report using both [68Ga]Ga-DOTANOC PET/CT and indigenous [99mTc]Tc-HYNIC-TATE SPECT/CT

Muhammad Hamza Hayat, Nayyar Rubab, Syed Fakhar Raza, Muhammad Talha, Muhammad Babar Imran.


Abstract
Background: Neuroendocrine tumors (NETs) are often well-differentiated and express somatostatin receptors (SSTRs), making functional imaging essential for accurate localization and staging. While [68Ga]Ga-DOTANOC PET/CT is preferred for its superior sensitivity, [99mTc]Tc-HYNIC-TATE SPECT/CT offers a viable alternative in settings with limited positron emission tomography (PET) access.
Case Description: We report a case of a 44-year-old patient diagnosed with a Grade 1 NET on tru-cut biopsy from retroperitoneal mass. To evaluate disease extent and SSTR expression, [⁶⁸Ga]Ga-DOTANOC PET/CT and [99mTc]Tc-HYNIC-TATE SPECT/CT were performed. Both imaging modalities demonstrated concordant findings with significant tracer uptake in a subhepatic lesion, retroperitoneal lymph nodes, and a hepatic lesion in segment V of the liver. These results confirmed the presence of both primary and metastatic disease, as well as high SSTR expression, indicating suitability for somatostatin analog therapy and possibly peptide receptor radionuclide therapy (PRRT).
Conclusion: This case illustrates that while [68Ga]Ga-DOTANOC PET/CT remains the gold standard of imaging, [99mTc]Tc-HYNICTATE SPECT/CT is a reliable alternative, particularly when PET is not available. The concordance between both modalities reinforces the diagnostic utility of [99mTc]Tc-HYNIC-TATE SPECT/CT in clinical practice.

Key words: SSRT, [⁶⁸Ga]Ga-DOTANOC PET/CT, [⁹⁹ᵐTc]Tc-HYNIC-TATE SPECT/CT, PRRT Peptide Receptor Radionuclide Therapy (PRRT).


 
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How to Cite this Article
Pubmed Style

Hayat MH, Rubab N, Raza SF, Talha M, Imran MB. Detection of soft tissue metastasis in a Grade-1 Neuroendocrine Tumor: a case report using both [68Ga]Ga-DOTANOC PET/CT and indigenous [99mTc]Tc-HYNIC-TATE SPECT/CT. Pak J Nucl Med. 2025; 15(1): 37-41. doi:10.24911/PJNMed.175-1759152750

Web Style

Hayat MH, Rubab N, Raza SF, Talha M, Imran MB. Detection of soft tissue metastasis in a Grade-1 Neuroendocrine Tumor: a case report using both [68Ga]Ga-DOTANOC PET/CT and indigenous [99mTc]Tc-HYNIC-TATE SPECT/CT. https://www.pjnmed.com/?mno=287262 [Access: January 11, 2026]. doi:10.24911/PJNMed.175-1759152750

AMA (American Medical Association) Style

Hayat MH, Rubab N, Raza SF, Talha M, Imran MB. Detection of soft tissue metastasis in a Grade-1 Neuroendocrine Tumor: a case report using both [68Ga]Ga-DOTANOC PET/CT and indigenous [99mTc]Tc-HYNIC-TATE SPECT/CT. Pak J Nucl Med. 2025; 15(1): 37-41. doi:10.24911/PJNMed.175-1759152750


Vancouver/ICMJE Style

Hayat MH, Rubab N, Raza SF, Talha M, Imran MB. Detection of soft tissue metastasis in a Grade-1 Neuroendocrine Tumor: a case report using both [68Ga]Ga-DOTANOC PET/CT and indigenous [99mTc]Tc-HYNIC-TATE SPECT/CT. Pak J Nucl Med. (2025), [cited January 11, 2026]; 15(1): 37-41. doi:10.24911/PJNMed.175-1759152750


Harvard Style

Hayat, M. H., Rubab, . N., Raza, . S. F., Talha, . M. & Imran, . M. B. (2025) Detection of soft tissue metastasis in a Grade-1 Neuroendocrine Tumor: a case report using both [68Ga]Ga-DOTANOC PET/CT and indigenous [99mTc]Tc-HYNIC-TATE SPECT/CT. Pak J Nucl Med, 15 (1), 37-41. doi:10.24911/PJNMed.175-1759152750


Turabian Style

Hayat, Muhammad Hamza, Nayyar Rubab, Syed Fakhar Raza, Muhammad Talha, and Muhammad Babar Imran. 2025. Detection of soft tissue metastasis in a Grade-1 Neuroendocrine Tumor: a case report using both [68Ga]Ga-DOTANOC PET/CT and indigenous [99mTc]Tc-HYNIC-TATE SPECT/CT. Pakistan Journal of Nuclear Medicine, 15 (1), 37-41. doi:10.24911/PJNMed.175-1759152750


Chicago Style

Hayat, Muhammad Hamza, Nayyar Rubab, Syed Fakhar Raza, Muhammad Talha, and Muhammad Babar Imran. "Detection of soft tissue metastasis in a Grade-1 Neuroendocrine Tumor: a case report using both [68Ga]Ga-DOTANOC PET/CT and indigenous [99mTc]Tc-HYNIC-TATE SPECT/CT." Pakistan Journal of Nuclear Medicine 15 (2025), 37-41. doi:10.24911/PJNMed.175-1759152750


MLA (The Modern Language Association) Style

Hayat, Muhammad Hamza, Nayyar Rubab, Syed Fakhar Raza, Muhammad Talha, and Muhammad Babar Imran. "Detection of soft tissue metastasis in a Grade-1 Neuroendocrine Tumor: a case report using both [68Ga]Ga-DOTANOC PET/CT and indigenous [99mTc]Tc-HYNIC-TATE SPECT/CT." Pakistan Journal of Nuclear Medicine 15.1 (2025), 37-41. Print. doi:10.24911/PJNMed.175-1759152750


APA (American Psychological Association) Style

Hayat, M. H., Rubab, . N., Raza, . S. F., Talha, . M. & Imran, . M. B. (2025) Detection of soft tissue metastasis in a Grade-1 Neuroendocrine Tumor: a case report using both [68Ga]Ga-DOTANOC PET/CT and indigenous [99mTc]Tc-HYNIC-TATE SPECT/CT. Pakistan Journal of Nuclear Medicine, 15 (1), 37-41. doi:10.24911/PJNMed.175-1759152750




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