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Case Report
Online Published: 09 Jan 2026
 


Rosai-Dorfman disease: uncommon meningeal presentation and insights from PET/CT imaging

Bensaid Chaymae, Hasnae Guerrouj, Manale Otmani, Ayat Mouaden, Imad Ghfir.


Abstract
Rosai-Dorfman disease (RDD) is a rare, benign histiocytic disorder of unclear etiology, most commonly presenting with lymphadenopathy - particularly in the cervical region - alongside systemic symptoms such as fever and elevated inflammatory markers. While nodal involvement is typical, extranodal manifestations can occur, and neurological involvement - though uncommon - may present as cerebral pachymeningitis or spinal cord abnormalities. 18F-FDG PET/CT has emerged as a valuable tool for early disease assessment and monitoring. We report the case of a 32-year-old patient with RDD presenting predominantly with meningeal involvement. The patient underwent surgical intervention, followed by treatment with corticosteroids and valproic acid (Depakine). Disease prognosis is closely linked to the extent of involvement. In this case, 18F-FDG PET/CT played a critical role in both treatment planning and response monitoring, demonstrating clear advantages over conventional computed tomography (CT) and Magnetic Resonance Imaging in evaluating disease activity.

Key words: Rosai-Dorfman disease, meningeal involvement, 18F-FDG PET/CT, extranodal histiocytosis.


 
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How to Cite this Article
Pubmed Style

Chaymae B, Guerrouj H, Otmani M, Mouaden A, Ghfir I. Rosai-Dorfman disease: uncommon meningeal presentation and insights from PET/CT imaging. Pak J Nucl Med. 2025; 15(1): 46-49. doi:10.24911/PJNMed.175-1721044363

Web Style

Chaymae B, Guerrouj H, Otmani M, Mouaden A, Ghfir I. Rosai-Dorfman disease: uncommon meningeal presentation and insights from PET/CT imaging. https://www.pjnmed.com/?mno=209983 [Access: January 11, 2026]. doi:10.24911/PJNMed.175-1721044363

AMA (American Medical Association) Style

Chaymae B, Guerrouj H, Otmani M, Mouaden A, Ghfir I. Rosai-Dorfman disease: uncommon meningeal presentation and insights from PET/CT imaging. Pak J Nucl Med. 2025; 15(1): 46-49. doi:10.24911/PJNMed.175-1721044363


Vancouver/ICMJE Style

Chaymae B, Guerrouj H, Otmani M, Mouaden A, Ghfir I. Rosai-Dorfman disease: uncommon meningeal presentation and insights from PET/CT imaging. Pak J Nucl Med. (2025), [cited January 11, 2026]; 15(1): 46-49. doi:10.24911/PJNMed.175-1721044363


Harvard Style

Chaymae, B., Guerrouj, . H., Otmani, . M., Mouaden, . A. & Ghfir, . I. (2025) Rosai-Dorfman disease: uncommon meningeal presentation and insights from PET/CT imaging. Pak J Nucl Med, 15 (1), 46-49. doi:10.24911/PJNMed.175-1721044363


Turabian Style

Chaymae, Bensaid, Hasnae Guerrouj, Manale Otmani, Ayat Mouaden, and Imad Ghfir. 2025. Rosai-Dorfman disease: uncommon meningeal presentation and insights from PET/CT imaging. Pakistan Journal of Nuclear Medicine, 15 (1), 46-49. doi:10.24911/PJNMed.175-1721044363


Chicago Style

Chaymae, Bensaid, Hasnae Guerrouj, Manale Otmani, Ayat Mouaden, and Imad Ghfir. "Rosai-Dorfman disease: uncommon meningeal presentation and insights from PET/CT imaging." Pakistan Journal of Nuclear Medicine 15 (2025), 46-49. doi:10.24911/PJNMed.175-1721044363


MLA (The Modern Language Association) Style

Chaymae, Bensaid, Hasnae Guerrouj, Manale Otmani, Ayat Mouaden, and Imad Ghfir. "Rosai-Dorfman disease: uncommon meningeal presentation and insights from PET/CT imaging." Pakistan Journal of Nuclear Medicine 15.1 (2025), 46-49. Print. doi:10.24911/PJNMed.175-1721044363


APA (American Psychological Association) Style

Chaymae, B., Guerrouj, . H., Otmani, . M., Mouaden, . A. & Ghfir, . I. (2025) Rosai-Dorfman disease: uncommon meningeal presentation and insights from PET/CT imaging. Pakistan Journal of Nuclear Medicine, 15 (1), 46-49. doi:10.24911/PJNMed.175-1721044363




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