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Online Publishing Date:
08 / 01 / 2023

 


PET-CT scan can be a reliable alternative to bone marrow Biopsy? Comparison of PET CT scan and marrow biopsy finding in diagnosed cases of lymphoma for staging

Anashia Kayani, Raheel Khan, Najwa Zahoor, Sara Khan, Asma Afzal, Gul Sanam, Aleena Ayesha.


Abstract
Objectives: To determine the diagnostic accuracy of 18F-labeled fluoro-2-deoxyglucose (18FDG) positron emission tomography/ computed tomography (18FDG-PET/CT) scan for identifying bone marrow involvement in diagnosed patients with lymphoma keeping bone marrow biopsy (BMB) as gold standard.
Study Design: cross-sectional study.
Setting: Department of Radiology, Armed Forces Institute of Radiological Imaging (AFIRI), Rawalpindi from April 26, 2021 to October 25, 2021.
Materials & Methods: A total of 128 cases of lymphoma of age 20-85 years and both genders were included. Patients who had taken treatment for lymphoma or were using bone marrow-stimulant factors or drugs before undergoing PET/CT scanning were excluded. PET/CT imaging was done at AFIRI 6 HD True point PET/CT 1 hour after intravenous injection of 0.2 mCi/kg 18FDG. PET acquisition was performed for 4 minutes per bed position for seven to eight bed positions. Bone marrow was classified into three types based on signal intensity and localization by FDG uptake on PT/CT as diffuse involvement, focal involvement, and normal bone marrow. Findings from 18FDG PET/CT were compared with BMB results for determining the diagnostic accuracy of abdominal FDG PET-CT.
Results: Overall sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy of 18FDG-PET/CT scan for identifying bone marrow involvement in diagnosed patients with lymphoma keeping BMB as gold standard was 95.45%, 93.55%, 94.03%, 95.08%, and 94.53%, respectively.
Conclusion: This study concluded that the diagnostic accuracy of 18FDG-PET/CT scan for identifying bone marrow involvement in diagnosed patients with lymphoma is very high.

Key words: Keywords: lymphoma, positron emission tomography/computed tomography, sensitivity


 
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How to Cite this Article
Pubmed Style

Kayani A, Khan R, Zahoor N, Khan S, Afzal A, Sanam G, Ayesha A. PET-CT scan can be a reliable alternative to bone marrow Biopsy? Comparison of PET CT scan and marrow biopsy finding in diagnosed cases of lymphoma for staging. Pak J Nucl Med. 2022; 12(1): 26-30. doi:10.24911/PJNMed.175-1655996967

Web Style

Kayani A, Khan R, Zahoor N, Khan S, Afzal A, Sanam G, Ayesha A. PET-CT scan can be a reliable alternative to bone marrow Biopsy? Comparison of PET CT scan and marrow biopsy finding in diagnosed cases of lymphoma for staging. https://www.pjnmed.com/?mno=67219 [Access: February 27, 2024]. doi:10.24911/PJNMed.175-1655996967

AMA (American Medical Association) Style

Kayani A, Khan R, Zahoor N, Khan S, Afzal A, Sanam G, Ayesha A. PET-CT scan can be a reliable alternative to bone marrow Biopsy? Comparison of PET CT scan and marrow biopsy finding in diagnosed cases of lymphoma for staging. Pak J Nucl Med. 2022; 12(1): 26-30. doi:10.24911/PJNMed.175-1655996967


Vancouver/ICMJE Style

Kayani A, Khan R, Zahoor N, Khan S, Afzal A, Sanam G, Ayesha A. PET-CT scan can be a reliable alternative to bone marrow Biopsy? Comparison of PET CT scan and marrow biopsy finding in diagnosed cases of lymphoma for staging. Pak J Nucl Med. (2022), [cited February 27, 2024]; 12(1): 26-30. doi:10.24911/PJNMed.175-1655996967


Harvard Style

Kayani, A., Khan, . R., Zahoor, . N., Khan, . S., Afzal, . A., Sanam, . G. & Ayesha, . A. (2022) PET-CT scan can be a reliable alternative to bone marrow Biopsy? Comparison of PET CT scan and marrow biopsy finding in diagnosed cases of lymphoma for staging. Pak J Nucl Med, 12 (1), 26-30. doi:10.24911/PJNMed.175-1655996967


Turabian Style

Kayani, Anashia, Raheel Khan, Najwa Zahoor, Sara Khan, Asma Afzal, Gul Sanam, and Aleena Ayesha. 2022. PET-CT scan can be a reliable alternative to bone marrow Biopsy? Comparison of PET CT scan and marrow biopsy finding in diagnosed cases of lymphoma for staging. Pakistan Journal of Nuclear Medicine, 12 (1), 26-30. doi:10.24911/PJNMed.175-1655996967


Chicago Style

Kayani, Anashia, Raheel Khan, Najwa Zahoor, Sara Khan, Asma Afzal, Gul Sanam, and Aleena Ayesha. "PET-CT scan can be a reliable alternative to bone marrow Biopsy? Comparison of PET CT scan and marrow biopsy finding in diagnosed cases of lymphoma for staging." Pakistan Journal of Nuclear Medicine 12 (2022), 26-30. doi:10.24911/PJNMed.175-1655996967


MLA (The Modern Language Association) Style

Kayani, Anashia, Raheel Khan, Najwa Zahoor, Sara Khan, Asma Afzal, Gul Sanam, and Aleena Ayesha. "PET-CT scan can be a reliable alternative to bone marrow Biopsy? Comparison of PET CT scan and marrow biopsy finding in diagnosed cases of lymphoma for staging." Pakistan Journal of Nuclear Medicine 12.1 (2022), 26-30. Print. doi:10.24911/PJNMed.175-1655996967


APA (American Psychological Association) Style

Kayani, A., Khan, . R., Zahoor, . N., Khan, . S., Afzal, . A., Sanam, . G. & Ayesha, . A. (2022) PET-CT scan can be a reliable alternative to bone marrow Biopsy? Comparison of PET CT scan and marrow biopsy finding in diagnosed cases of lymphoma for staging. Pakistan Journal of Nuclear Medicine, 12 (1), 26-30. doi:10.24911/PJNMed.175-1655996967




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