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Online Publishing Date:
07 / 06 / 2022

 


Prognostic factors pertaining to disease-free status in differentiated thyroid carcinoma patients

Aniqa Jabeen, Lubna Khan Jadoon, Sumaira Mushtaq, Syed Minhaj Maqbool, Bashir Ahmed, Hina Hashmi.


Abstract
Background: Radioiodine resistance in differentiated thyroid cancer (DTC) and unsuccessful ablation may adversely affect the prognosis of patients with DTC; therefore, identifying the factors that affect the success of ablation is very important in the management of patients with DTC. Our goal was to assess the factors associated with DTC after thyroidectomy and radioactive iodine ablation for achievement of disease-free status.
Methods: This was a retrospective study in which 277 patients were included. Age, gender, extent of thyroid surgery, tumor size, nodal metastases, distant metastases, and pre-ablation thyroglobulin (Tg) were analyzed initially in univariate analysis and then with significant variables by multivariate analysis.
Results: On univariate analysis, variables such as pre-ablated stimulated Tg level ≤ 20 ng/ml, absence of locoregional and distant metastases, tumor ≤ 4 cm, total thyroidectomy, and low and intermediate risk groups appeared to be significant. On multivariate analysis, stimulated Tg level ≤ 20 ng/ml, absence of locoregional metastases, and total thyroidectomy were associated with disease-free status.
Conclusion: The most important predictors for succeeding a disease-free status were low pre-ablation Tg level, i.e., 20 ng/ml, appropriate total thyroidectomy, and absence of lymph node metastasis.

Key words: Differentiated thyroid carcinoma, good prognosis, radioiodine therapy, disease-free status, Thyroglobulin (Tg)


 
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How to Cite this Article
Pubmed Style

Jabeen A, Jadoon LK, Mushtaq S, Maqbool SM, Ahmed B, Hashmi H. Prognostic factors pertaining to disease-free status in differentiated thyroid carcinoma patients. Pak J Nucl Med. 2022; 12(1): 09-17. doi:10.24911/PJNMed.175-1625415854

Web Style

Jabeen A, Jadoon LK, Mushtaq S, Maqbool SM, Ahmed B, Hashmi H. Prognostic factors pertaining to disease-free status in differentiated thyroid carcinoma patients. https://www.pjnmed.com/?mno=93080 [Access: February 28, 2024]. doi:10.24911/PJNMed.175-1625415854

AMA (American Medical Association) Style

Jabeen A, Jadoon LK, Mushtaq S, Maqbool SM, Ahmed B, Hashmi H. Prognostic factors pertaining to disease-free status in differentiated thyroid carcinoma patients. Pak J Nucl Med. 2022; 12(1): 09-17. doi:10.24911/PJNMed.175-1625415854


Vancouver/ICMJE Style

Jabeen A, Jadoon LK, Mushtaq S, Maqbool SM, Ahmed B, Hashmi H. Prognostic factors pertaining to disease-free status in differentiated thyroid carcinoma patients. Pak J Nucl Med. (2022), [cited February 28, 2024]; 12(1): 09-17. doi:10.24911/PJNMed.175-1625415854


Harvard Style

Jabeen, A., Jadoon, . L. K., Mushtaq, . S., Maqbool, . S. M., Ahmed, . B. & Hashmi, . H. (2022) Prognostic factors pertaining to disease-free status in differentiated thyroid carcinoma patients. Pak J Nucl Med, 12 (1), 09-17. doi:10.24911/PJNMed.175-1625415854


Turabian Style

Jabeen, Aniqa, Lubna Khan Jadoon, Sumaira Mushtaq, Syed Minhaj Maqbool, Bashir Ahmed, and Hina Hashmi. 2022. Prognostic factors pertaining to disease-free status in differentiated thyroid carcinoma patients. Pakistan Journal of Nuclear Medicine, 12 (1), 09-17. doi:10.24911/PJNMed.175-1625415854


Chicago Style

Jabeen, Aniqa, Lubna Khan Jadoon, Sumaira Mushtaq, Syed Minhaj Maqbool, Bashir Ahmed, and Hina Hashmi. "Prognostic factors pertaining to disease-free status in differentiated thyroid carcinoma patients." Pakistan Journal of Nuclear Medicine 12 (2022), 09-17. doi:10.24911/PJNMed.175-1625415854


MLA (The Modern Language Association) Style

Jabeen, Aniqa, Lubna Khan Jadoon, Sumaira Mushtaq, Syed Minhaj Maqbool, Bashir Ahmed, and Hina Hashmi. "Prognostic factors pertaining to disease-free status in differentiated thyroid carcinoma patients." Pakistan Journal of Nuclear Medicine 12.1 (2022), 09-17. Print. doi:10.24911/PJNMed.175-1625415854


APA (American Psychological Association) Style

Jabeen, A., Jadoon, . L. K., Mushtaq, . S., Maqbool, . S. M., Ahmed, . B. & Hashmi, . H. (2022) Prognostic factors pertaining to disease-free status in differentiated thyroid carcinoma patients. Pakistan Journal of Nuclear Medicine, 12 (1), 09-17. doi:10.24911/PJNMed.175-1625415854




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