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Original Article
Pak J Nucl Med. 2021; 11(1): 0-0

I131 myth bursting: Association of pregnancy/infertility related adverse effects of radioactive iodine I131 administration

Authors: Ayesha Ammar, Shazia Fatima, Kahkashan Bashir, Noreen Marwat, Sadaf Batool, Adnan Saeed, Muhammad Faheem, Maryam Syed.

View PDF HTML FullText DOI: 10.24911/PJNMed.175-1617536800

Abstract

Background: There is very little knowledge on the risks of genetically transmissible diseases after the exposure to radiation. This study aimed to investigate the influence of radioiodine (RAI) therapy on the outcome of pregnancies and the health status of children born to mothers who had received therapeutic doses of I-131 for differentiated thyroid carcinoma (DTC) or for hyperthyroidism. Methods: Gestational histories of 300 women who were treated with radioactive iodine either for the treatment of hyperthyroidism or for the treatment of thyroid cancer from 2012-2017 were retrospectively analyzed. Two Groups were made on the basis of administered doses of radioactive iodine. The first group was further divided into two sub groups. Sub group A consisted of the patients who were treated with radioactive iodine for hyperthyroidism with less than 30 mCi. Sub Group B had patients of differentiated thyroid cancer that had been treated with doses above 100 mCi of I-131. Group 2 had patients with primary hypothyroidism and was on thyroxine replacement therapy. Control group consists of healthy young women with no co-morbids delivered babies in this time interval. Results: The outcome of the 200 patients were as follows: 97 live births in the group A and 10 miscarriages, while in high dose group 85 live births and 8 miscarriages were recorded versus 44 live births and 6 miscarriages in the group who were primary hypothyroid. In the control group there were 50 patients who had 3 miscarriage and 47 healthy babies. Conclusion: So, the present study concluded that radioactive iodine administration does not increased a women risk of infertility or early pregnancy failure.

Keywords:   Pregnancy, radioactive iodine, hyperthyroidism, cancer thyroid, thyroxine


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I131 myth bursting: Association of pregnancy/infertility related adverse effects of radioactive iodine I131 administration


Authors
Ayesha Ammar
Pakistan Atomic Energy Cancer Hospital (AECH), NORI, Islamabad, Pakistan
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Shazia Fatima
Pakistan Atomic Energy Cancer Hospital (AECH), NORI, Islamabad, Pakistan
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Kahkashan Bashir
Pakistan Atomic Energy Cancer Hospital (AECH), NORI, Islamabad, Pakistan
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Noreen Marwat
Pakistan Atomic Energy Cancer Hospital (AECH), NORI, Islamabad, Pakistan
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Sadaf Batool
Pakistan Atomic Energy Cancer Hospital (AECH), NORI, Islamabad, Pakistan
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Adnan Saeed
Pakistan Atomic Energy Cancer Hospital (AECH), NORI, Islamabad, Pakistan
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Muhammad Faheem
Pakistan Atomic Energy Cancer Hospital (AECH), NORI, Islamabad, Pakistan
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Maryam Syed
Shifa College of Medicine, Islamabad, Pakistan
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Correspondence to:
. Ayesha Ammar, Pakistan Atomic Energy Cancer Hospital (AECH), NORI, Islamabad, Pakistan; ayeshaammar25308@gmail.com

Publication history
Received 04 Apr 2021
Revised 19 May 2021
Accepted 22 May 2021
Published online 29 Jun 2021
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How to cite this article

Pubmed Style

Ammar A, Fatima S, Bashir K, Marwat N, Batool S, Saeed A, Faheem M, Syed M. I131 myth bursting: Association of pregnancy/infertility related adverse effects of radioactive iodine I131 administration. doi:10.24911/PJNMed.175-1617536800


Web Style

Ammar A, Fatima S, Bashir K, Marwat N, Batool S, Saeed A, Faheem M, Syed M. I131 myth bursting: Association of pregnancy/infertility related adverse effects of radioactive iodine I131 administration. http://www.pjnmed.com/?mno=70312 [Access: September 19, 2021]. doi:10.24911/PJNMed.175-1617536800


AMA (American Medical Association) Style

Ammar A, Fatima S, Bashir K, Marwat N, Batool S, Saeed A, Faheem M, Syed M. I131 myth bursting: Association of pregnancy/infertility related adverse effects of radioactive iodine I131 administration. doi:10.24911/PJNMed.175-1617536800


Vancouver/ICMJE Style

Ammar A, Fatima S, Bashir K, Marwat N, Batool S, Saeed A, Faheem M, Syed M. I131 myth bursting: Association of pregnancy/infertility related adverse effects of radioactive iodine I131 administration. doi:10.24911/PJNMed.175-1617536800


Harvard Style

Ammar, A., Fatima, . S., Bashir, . K., Marwat, . N., Batool, . S., Saeed, . A., Faheem, . M. & Syed, . M. (2021) I131 myth bursting: Association of pregnancy/infertility related adverse effects of radioactive iodine I131 administration. doi:10.24911/PJNMed.175-1617536800


Turabian Style

Ammar, Ayesha, Shazia Fatima, Kahkashan Bashir, Noreen Marwat, Sadaf Batool, Adnan Saeed, Muhammad Faheem, and Maryam Syed. 2021. I131 myth bursting: Association of pregnancy/infertility related adverse effects of radioactive iodine I131 administration. doi:10.24911/PJNMed.175-1617536800


Chicago Style

Ammar, Ayesha, Shazia Fatima, Kahkashan Bashir, Noreen Marwat, Sadaf Batool, Adnan Saeed, Muhammad Faheem, and Maryam Syed. "I131 myth bursting: Association of pregnancy/infertility related adverse effects of radioactive iodine I131 administration." doi:10.24911/PJNMed.175-1617536800


MLA (The Modern Language Association) Style

Ammar, Ayesha, Shazia Fatima, Kahkashan Bashir, Noreen Marwat, Sadaf Batool, Adnan Saeed, Muhammad Faheem, and Maryam Syed. "I131 myth bursting: Association of pregnancy/infertility related adverse effects of radioactive iodine I131 administration." doi:10.24911/PJNMed.175-1617536800


APA (American Psychological Association) Style

Ammar, A., Fatima, . S., Bashir, . K., Marwat, . N., Batool, . S., Saeed, . A., Faheem, . M. & Syed, . M. (2021) I131 myth bursting: Association of pregnancy/infertility related adverse effects of radioactive iodine I131 administration. doi:10.24911/PJNMed.175-1617536800


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