;
Original Article
Pak J Nucl Med. 2020; 10(1): 27-30

Theoretical comparison of absorbed dose estimation using dose commitment formula and medical internal radiation dose in radioactive iodine-131 therapy

Authors: Javaid Ali, Aakif Ullah Khan, Shujat Ali.

View PDF HTML FullText DOI: 10.24911/PJNMed.175-1536901517

Abstract

Background: Radioactive iodine-131 (RAI-131) is used for the treatment and diagnosis of thyroid disorder. It is commonly used for internal radionuclide therapy of hyperthyroidism and differentiated thyroid cancer. The estimation of absorbed dose to thyroid remnants/tumors is the concern of nuclear physicians in RAI-131 therapy of carcinoma thyroid patients. The purpose of this study is to compare theoretically the estimated absorbed dose to thyroid remnants/tumors by dose commitment formula and medical internal radiation dose (MIRD) in RAI-131 therapy. The study is significant to recognize the limitations and advantages of the two techniques compared. Methods: The absorbed doses to 21 different masses of thyroid remnants/tumors were estimated from MIRD and dose commitment formula; however, the residence time (τ), percentage uptake (%U), and initial administered activities (A0) were kept fixed. The previously published S-values of different masses of thyroid remnants/tumors were used in the study. The mean percentage difference and variation factor of absorbed doses between the two techniques were also measured. Results: It was observed that the mean percentage difference between the two methods was 18.24% with a standard deviation of 19.25. However, the mean variation factor between the two methods was found to be 1.0687 (min: 0.766712 and max: 2.784375) with a standard deviation of 0.422885. Conclusion: It is concluded that the methods are well matched only for some masses of thyroid remnants/tumors [3/21] but not for other masses [18/21]. It is also concluded that dose commitment formula can be used as an alternative to estimate the absorbed dose to single thyroid remnant/tumor as it is more useful than MIRD, because of some limitation of S-values in MIRD.

Keywords:   Absorbed dose, RAI-131 therapy, MIRD, dose commitment


Request permissions

If you wish to reuse any part or all of this article please contact the copyright holder, contact@pjnmed.com.

Copyright © 2020 Discover STM Publishing. All Rights Reserved.

Theoretical comparison of absorbed dose estimation using dose commitment formula and medical internal radiation dose in radioactive iodine-131 therapy


Authors
Javaid Ali
Swat Institute of Nuclear Medicine, Oncology and Radiotherapy (SINOR), Swat, Pakistan
PubMed articlesGoogle scholar articles

Aakif Ullah Khan
Institute of Radiotherapy and Nuclear Medicine (IRNUM), Peshawar, Pakistan
PubMed articlesGoogle scholar articles

Shujat Ali
Swat Institute of Nuclear Medicine, Oncology and Radiotherapy (SINOR), Swat, Pakistan
PubMed articlesGoogle scholar articles


Correspondence to:
. Javaid Ali, Swat Institute of Nuclear Medicine, Oncology and Radiotherapy (SINOR), Swat, Pakistan.; javaidalitarakai@gmail.com, javid.tarakai@yahoo.com

Publication history
Received 14 Sep 2018
Revised 30 Mar 2020
Accepted 21 Apr 2020
Published online 23 May 2020
Published in print 11 Sep 2020
Export to EndNote Export to refMan

How to cite this article

Pubmed Style

Ali J, Khan AU, Ali S. Theoretical comparison of absorbed dose estimation using dose commitment formula and medical internal radiation dose in radioactive iodine-131 therapy. Pak J Nucl Med. 2020; 10(1): 27-30. doi:10.24911/PJNMed.175-1536901517


Web Style

Ali J, Khan AU, Ali S. Theoretical comparison of absorbed dose estimation using dose commitment formula and medical internal radiation dose in radioactive iodine-131 therapy. http://www.pjnmed.com/?mno=8447 [Access: August 02, 2021]. doi:10.24911/PJNMed.175-1536901517


AMA (American Medical Association) Style

Ali J, Khan AU, Ali S. Theoretical comparison of absorbed dose estimation using dose commitment formula and medical internal radiation dose in radioactive iodine-131 therapy. Pak J Nucl Med. 2020; 10(1): 27-30. doi:10.24911/PJNMed.175-1536901517


Vancouver/ICMJE Style

Ali J, Khan AU, Ali S. Theoretical comparison of absorbed dose estimation using dose commitment formula and medical internal radiation dose in radioactive iodine-131 therapy. Pak J Nucl Med. (2020), [cited August 02, 2021]; 10(1): 27-30. doi:10.24911/PJNMed.175-1536901517


Harvard Style

Ali, J., Khan, . A. U. & Ali, . S. (2020) Theoretical comparison of absorbed dose estimation using dose commitment formula and medical internal radiation dose in radioactive iodine-131 therapy. Pak J Nucl Med, 10 (1), 27-30. doi:10.24911/PJNMed.175-1536901517


Turabian Style

Ali, Javaid, Aakif Ullah Khan, and Shujat Ali. 2020. Theoretical comparison of absorbed dose estimation using dose commitment formula and medical internal radiation dose in radioactive iodine-131 therapy. Pakistan Journal of Nuclear Medicine, 10 (1), 27-30. doi:10.24911/PJNMed.175-1536901517


Chicago Style

Ali, Javaid, Aakif Ullah Khan, and Shujat Ali. "Theoretical comparison of absorbed dose estimation using dose commitment formula and medical internal radiation dose in radioactive iodine-131 therapy." Pakistan Journal of Nuclear Medicine 10 (2020), 27-30. doi:10.24911/PJNMed.175-1536901517


MLA (The Modern Language Association) Style

Ali, Javaid, Aakif Ullah Khan, and Shujat Ali. "Theoretical comparison of absorbed dose estimation using dose commitment formula and medical internal radiation dose in radioactive iodine-131 therapy." Pakistan Journal of Nuclear Medicine 10.1 (2020), 27-30. Print. doi:10.24911/PJNMed.175-1536901517


APA (American Psychological Association) Style

Ali, J., Khan, . A. U. & Ali, . S. (2020) Theoretical comparison of absorbed dose estimation using dose commitment formula and medical internal radiation dose in radioactive iodine-131 therapy. Pakistan Journal of Nuclear Medicine, 10 (1), 27-30. doi:10.24911/PJNMed.175-1536901517


Click the icon of the social media platform on which you would like to share this article.