;
Original Article
Pak J Nucl Med. 2020; 10(1): 31-37

99mTc-MDP renal parenchymal retention on bone scan in hepatocellular carcinoma patients

Authors: Muhammad Shahzad Afzal, Muhammad Babar Imran, Samen Fatima, Muhammad Iqbal, Farkhanda Gillani, Nayyar Rubab, Owais Qadeer Gill, Muhammad Naeem.

View PDF HTML FullText DOI: 10.24911/PJNMed.175-1574674085

Abstract

Background: Hot kidneys had been reported on bone scan in few patients with hepatocellular carcinoma (HCC), but their cause is unknown. This study was conducted to compare the 99mTc-MDP renal parenchymal retention on bone scan in HCC patients with normal controls and chronic liver disease (CLD) patients and to correlate it in HCC patients with glomerular filtration rate (GFR). Methods: Fifteen normal, 15 CLD, and 85 HCC patients with normal serum urea and creatinine underwent bone scan. Renal parenchymal retention index (PRI) in terms of the kidney-to-lumbar vertebrae counts ratio was calculated, and its mean was compared between these three groups by using Studentís t-test. Last consecutive 25 HCC patients underwent 99mTc DTPA dynamic renal scan, and mean PRI in patients with normal GFR (group I, n = 6) was compared with those with deranged GFR (group II, n = 19). Results: Mean PRI was 26.8% higher in CLD patients than control group (p = 0.000). Mean PRI in HCC group was 99.7% higher than control (p = 0.000) and 59.6% higher than that of CLD group (p = 0.004). GFR was deranged in 76% of HCC patients. Mean PRI was 36.9% higher in group II than group I at p = 0.023. Conclusion: Renal parenchymal retention on bone scan is significantly higher in HCC patients than normal control and CLD patients. In HCC patients, it was significantly higher in patients with reduced GFR than those with normal GFR.

Keywords:   Hot kidney, renal parenchymal retention of MDP, hepatocellular CA, HCC, renal parenchymal retention index


Request permissions

If you wish to reuse any part or all of this article please contact the copyright holder, contact@pjnmed.com.

Copyright © 2020 Discover STM Publishing. All Rights Reserved.

99mTc-MDP renal parenchymal retention on bone scan in hepatocellular carcinoma patients


Authors
Muhammad Shahzad Afzal
PINUM Cancer Hospital, Faisalabad, Pakistan
PubMed articlesGoogle scholar articles

Muhammad Babar Imran
PINUM Cancer Hospital, Faisalabad, Pakistan
PubMed articlesGoogle scholar articles

Samen Fatima
PINUM Cancer Hospital, Faisalabad, Pakistan
PubMed articlesGoogle scholar articles

Muhammad Iqbal
PINUM Cancer Hospital, Faisalabad, Pakistan
PubMed articlesGoogle scholar articles

Farkhanda Gillani
PINUM Cancer Hospital, Faisalabad, Pakistan
PubMed articlesGoogle scholar articles

Nayyar Rubab
PINUM Cancer Hospital, Faisalabad, Pakistan
PubMed articlesGoogle scholar articles

Owais Qadeer Gill
PINUM Cancer Hospital, Faisalabad, Pakistan
PubMed articlesGoogle scholar articles

Muhammad Naeem
PINUM Cancer Hospital, Faisalabad, Pakistan
PubMed articlesGoogle scholar articles


Correspondence to:
. Muhammad Shahzad Afzal, PINUM (Punjab Institute of Nuclear Medicine) Cancer Hospital, Faisalabad, Pakistan.; msamirza@yahoo.com

Publication history
Received 30 Dec 2019
Revised 16 May 2020
Accepted 07 Jul 2020
Published online 02 Aug 2020
Published in print 11 Sep 2020
Export to EndNote Export to refMan

How to cite this article

Pubmed Style

Afzal MS, Imran MB, Fatima S, Iqbal M, Gillani F, Rubab N, Gill OQ, Naeem M. 99mTc-MDP renal parenchymal retention on bone scan in hepatocellular carcinoma patients. Pak J Nucl Med. 2020; 10(1): 31-37. doi:10.24911/PJNMed.175-1574674085


Web Style

Afzal MS, Imran MB, Fatima S, Iqbal M, Gillani F, Rubab N, Gill OQ, Naeem M. 99mTc-MDP renal parenchymal retention on bone scan in hepatocellular carcinoma patients. http://www.pjnmed.com/?mno=75251 [Access: August 02, 2021]. doi:10.24911/PJNMed.175-1574674085


AMA (American Medical Association) Style

Afzal MS, Imran MB, Fatima S, Iqbal M, Gillani F, Rubab N, Gill OQ, Naeem M. 99mTc-MDP renal parenchymal retention on bone scan in hepatocellular carcinoma patients. Pak J Nucl Med. 2020; 10(1): 31-37. doi:10.24911/PJNMed.175-1574674085


Vancouver/ICMJE Style

Afzal MS, Imran MB, Fatima S, Iqbal M, Gillani F, Rubab N, Gill OQ, Naeem M. 99mTc-MDP renal parenchymal retention on bone scan in hepatocellular carcinoma patients. Pak J Nucl Med. (2020), [cited August 02, 2021]; 10(1): 31-37. doi:10.24911/PJNMed.175-1574674085


Harvard Style

Afzal, M. S., Imran, . M. B., Fatima, . S., Iqbal, . M., Gillani, . F., Rubab, . N., Gill, . O. Q. & Naeem, . M. (2020) 99mTc-MDP renal parenchymal retention on bone scan in hepatocellular carcinoma patients. Pak J Nucl Med, 10 (1), 31-37. doi:10.24911/PJNMed.175-1574674085


Turabian Style

Afzal, Muhammad Shahzad, Muhammad Babar Imran, Samen Fatima, Muhammad Iqbal, Farkhanda Gillani, Nayyar Rubab, Owais Qadeer Gill, and Muhammad Naeem. 2020. 99mTc-MDP renal parenchymal retention on bone scan in hepatocellular carcinoma patients. Pakistan Journal of Nuclear Medicine, 10 (1), 31-37. doi:10.24911/PJNMed.175-1574674085


Chicago Style

Afzal, Muhammad Shahzad, Muhammad Babar Imran, Samen Fatima, Muhammad Iqbal, Farkhanda Gillani, Nayyar Rubab, Owais Qadeer Gill, and Muhammad Naeem. "99mTc-MDP renal parenchymal retention on bone scan in hepatocellular carcinoma patients." Pakistan Journal of Nuclear Medicine 10 (2020), 31-37. doi:10.24911/PJNMed.175-1574674085


MLA (The Modern Language Association) Style

Afzal, Muhammad Shahzad, Muhammad Babar Imran, Samen Fatima, Muhammad Iqbal, Farkhanda Gillani, Nayyar Rubab, Owais Qadeer Gill, and Muhammad Naeem. "99mTc-MDP renal parenchymal retention on bone scan in hepatocellular carcinoma patients." Pakistan Journal of Nuclear Medicine 10.1 (2020), 31-37. Print. doi:10.24911/PJNMed.175-1574674085


APA (American Psychological Association) Style

Afzal, M. S., Imran, . M. B., Fatima, . S., Iqbal, . M., Gillani, . F., Rubab, . N., Gill, . O. Q. & Naeem, . M. (2020) 99mTc-MDP renal parenchymal retention on bone scan in hepatocellular carcinoma patients. Pakistan Journal of Nuclear Medicine, 10 (1), 31-37. doi:10.24911/PJNMed.175-1574674085


Click the icon of the social media platform on which you would like to share this article.