;
Original Article
Pak J Nucl Med. 2021; 11(1): 0-0

The impact of varying number of OSEM iterations on Standardized Uptake Value (SUV) and image quality of PET/CT Scan

Authors: Babar Ali, Afshan Ashfaq, Muhammad Basim Kakakhel.

View PDF HTML FullText DOI: 10.24911/PJNMed.175-1599635121

Abstract

Background: In PET scan reporting, both quantitative and qualitative interpretations are used. Qualitative and quantitative interpretations depend upon PET/CT image quality that, along with many biological factors, strongly depends upon image reconstruction parameters. This study intends to evaluate one of the key reconstruction parameters, i.e. the number of reconstruction iteration on SUV and the image quality of PET/CT scan. Methods: Images of NEMA IEC Image Quality Phantom (tumor to background ratio of 4:1, 18F-FDG as a radiotracer) were acquired on Discovery STE PET/CT scanner acquisition time of 5 mins. Acquired data were reconstructed using 2, 3, 4, 5, 7, 10, 15 and 20 OSEM iterations of iterative reconstruction. Results: Quantitative measure SUV and qualitative measure hot and cold lesion contrast, image's spatial resolution and background variability showed an increasing trend with OSEM iterations. A maximum increase of 20.25%, 16.33%, 9.79% and 6.88% was observed in SUV for 10mm, 13mm, 17mm and 22mm lesions for OSEM iterations varying from 2 to 3. Percentage hot lesion contrast showed a rapid increase as the number of iterations changed from 2 to 7 and increased slowly afterward. The percentage background variability showed an increasing trend for each lesion with OSEM iterations. Conclusion: Optimized number of OSEM iterations is 3 with an image matrix size of 128 128 with filters FWHM of 6mm. High-resolution studies require three iterations with an image matrix size of 256 256 with filters FWHM of 6mm. Extended reconstruction time limits the use of a higher number of iterations.

Keywords:   SUV, PET/CT, Hot Lesion Contrast, Cold Lesion Contrast, OSEM, Iterations, FDG, Background Variability


Request permissions

If you wish to reuse any part or all of this article please contact the copyright holder, contact@pjnmed.com.

Copyright © 2020 Discover STM Publishing. All Rights Reserved.

The impact of varying number of OSEM iterations on Standardized Uptake Value (SUV) and image quality of PET/CT Scan


Authors
Babar Ali
Dera Ismael Khan Institute of Nuclear Medicine and Radiotherapy (DINAR), Pakistan
PubMed articlesGoogle scholar articles

Afshan Ashfaq
Institute of Nuclear Medicine and Oncology (INMOL), Lahore, Punjab, Pakistan
PubMed articlesGoogle scholar articles

Muhammad Basim Kakakhel
Pakistan Institute of Engineering and Applied Sciences (PIEAS), Nilore, Islamabad, Pakistan
PubMed articlesGoogle scholar articles


Correspondence to:
. Babar Ali, Dera Ismael Khan Institute of Nuclear Medicine and Radiotherapy (DINAR), Pakistan; babarinphysics@gmail.com

Publication history
Received 09 Sep 2020
Revised 14 Mar 2021
Accepted 14 Mar 2021
Published online 30 May 2021
Export to EndNote Export to refMan

How to cite this article

Pubmed Style

Ali B, Ashfaq A, Kakakhel MB. The impact of varying number of OSEM iterations on Standardized Uptake Value (SUV) and image quality of PET/CT Scan. doi:10.24911/PJNMed.175-1599635121


Web Style

Ali B, Ashfaq A, Kakakhel MB. The impact of varying number of OSEM iterations on Standardized Uptake Value (SUV) and image quality of PET/CT Scan. http://www.pjnmed.com/?mno=133041 [Access: August 02, 2021]. doi:10.24911/PJNMed.175-1599635121


AMA (American Medical Association) Style

Ali B, Ashfaq A, Kakakhel MB. The impact of varying number of OSEM iterations on Standardized Uptake Value (SUV) and image quality of PET/CT Scan. doi:10.24911/PJNMed.175-1599635121


Vancouver/ICMJE Style

Ali B, Ashfaq A, Kakakhel MB. The impact of varying number of OSEM iterations on Standardized Uptake Value (SUV) and image quality of PET/CT Scan. doi:10.24911/PJNMed.175-1599635121


Harvard Style

Ali, B., Ashfaq, . A. & Kakakhel, . M. B. (2021) The impact of varying number of OSEM iterations on Standardized Uptake Value (SUV) and image quality of PET/CT Scan. doi:10.24911/PJNMed.175-1599635121


Turabian Style

Ali, Babar, Afshan Ashfaq, and Muhammad Basim Kakakhel. 2021. The impact of varying number of OSEM iterations on Standardized Uptake Value (SUV) and image quality of PET/CT Scan. doi:10.24911/PJNMed.175-1599635121


Chicago Style

Ali, Babar, Afshan Ashfaq, and Muhammad Basim Kakakhel. "The impact of varying number of OSEM iterations on Standardized Uptake Value (SUV) and image quality of PET/CT Scan." doi:10.24911/PJNMed.175-1599635121


MLA (The Modern Language Association) Style

Ali, Babar, Afshan Ashfaq, and Muhammad Basim Kakakhel. "The impact of varying number of OSEM iterations on Standardized Uptake Value (SUV) and image quality of PET/CT Scan." doi:10.24911/PJNMed.175-1599635121


APA (American Psychological Association) Style

Ali, B., Ashfaq, . A. & Kakakhel, . M. B. (2021) The impact of varying number of OSEM iterations on Standardized Uptake Value (SUV) and image quality of PET/CT Scan. doi:10.24911/PJNMed.175-1599635121


Click the icon of the social media platform on which you would like to share this article.