E-ISSN 2305-1620 | ISSN 2221-0288
 

Original Research (Original Article) Open Access


Vitamin B12 deficiency: prevalence and evaluation of a reversible co-morbidity in hypothyroid patients

Aniqa Jabeen, Sumaira Mushtaq, Hassan Raza, Mohammd Ali Memon.

Abstract
Aims: The study aimed at assessing the prevalence and clinical features of vitamin B12 deficiency in hypothyroid patients and to evaluate clinical response to vitamin B12 replacement therapy. <br> Methods: A total of 204 vitamin B12 deficient patients with primary hypothyroidism who attended the thyroid clinic at the nuclear medicine department of Atomic Energy Medical Centre Karachi, were included in the study. Signs and symptoms, haemoglobin (Hb), mean corpuscular volume (MCV), thyroid function tests and B12 levels were recorded. Patients with low levels of B12 or who had symptoms suggestive of B12 deficiency were given oral vitamin B12 treatment and monitored for improvement. <br> Results: A total of 204 hypothyroid patients (197 females, 7 males) were evaluated. 92 of 204 patients (45.09%) had low vitamin B12 levels. Depression (p value 0.000082), weakness (p value 0.0018), numbness (p value 0.022), paraesthesia (p value 0.018), and impaired memory (p value 0.027) were statistically significant in B12-deficient hypothyroid patients. B12-deficient patients had increased prevalence of anaemia than the sufficient group (32.6% vs. 22.02%). 92 B12-deficient and 70 B12-sufficient patients with symptoms of B12 deficiency were started on oral vitamin B12 and improvement noted. <br> Conclusion: There is a high (45%) prevalence of B12 deficiency in hypothyroid patients. Screening of vitamin B12 levels should be undertaken in all hypothyroid patients in the early course of the disease as it is a potentially reversible condition. Weakness, numbness and neuropsychiatric symptoms point towards B12 deficiency. Replacement of B12 leads to improvement in symptoms; however, placebo effect should be taken into consideration.


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Export to
Export to
Related Records
 Articles by Aniqa Jabeen
Articles by Sumaira Mushtaq
Articles by Hassan Raza
Articles by Mohammd Ali Memon
on Google
on Google Scholar
Article Statistics
 Viewed: 123
Downloaded: 27
Cited: 0

How to Cite this Article
Pubmed Style

Jabeen A, Mushtaq S, Raza H, Memon MA. Vitamin B12 deficiency: prevalence and evaluation of a reversible co-morbidity in hypothyroid patients. PJNM. 2016; 6(1): 25-31.


Web Style

Jabeen A, Mushtaq S, Raza H, Memon MA. Vitamin B12 deficiency: prevalence and evaluation of a reversible co-morbidity in hypothyroid patients. http://www.pjnmed.com/?mno=284653 [Access: February 18, 2018].


AMA (American Medical Association) Style

Jabeen A, Mushtaq S, Raza H, Memon MA. Vitamin B12 deficiency: prevalence and evaluation of a reversible co-morbidity in hypothyroid patients. PJNM. 2016; 6(1): 25-31.



Vancouver/ICMJE Style

Jabeen A, Mushtaq S, Raza H, Memon MA. Vitamin B12 deficiency: prevalence and evaluation of a reversible co-morbidity in hypothyroid patients. PJNM. (2016), [cited February 18, 2018]; 6(1): 25-31.



Harvard Style

Jabeen, A., Mushtaq, S., Raza, H. & Memon, M. A. (2016) Vitamin B12 deficiency: prevalence and evaluation of a reversible co-morbidity in hypothyroid patients. PJNM, 6 (1), 25-31.



Turabian Style

Jabeen, Aniqa, Sumaira Mushtaq, Hassan Raza, and Mohammd Ali Memon. 2016. Vitamin B12 deficiency: prevalence and evaluation of a reversible co-morbidity in hypothyroid patients. Pakistan Journal of Nuclear Medicine, 6 (1), 25-31.



Chicago Style

Jabeen, Aniqa, Sumaira Mushtaq, Hassan Raza, and Mohammd Ali Memon. "Vitamin B12 deficiency: prevalence and evaluation of a reversible co-morbidity in hypothyroid patients." Pakistan Journal of Nuclear Medicine 6 (2016), 25-31.



MLA (The Modern Language Association) Style

Jabeen, Aniqa, Sumaira Mushtaq, Hassan Raza, and Mohammd Ali Memon. "Vitamin B12 deficiency: prevalence and evaluation of a reversible co-morbidity in hypothyroid patients." Pakistan Journal of Nuclear Medicine 6.1 (2016), 25-31. Print.



APA (American Psychological Association) Style

Jabeen, A., Mushtaq, S., Raza, H. & Memon, M. A. (2016) Vitamin B12 deficiency: prevalence and evaluation of a reversible co-morbidity in hypothyroid patients. Pakistan Journal of Nuclear Medicine, 6 (1), 25-31.





Most Viewed Articles
  • Lactate dehydrogenase (LDH) as predictive factor of the pain free syndrome duration after radionuclide treatment of bone metastases in patients with breast cancer
    Nigora Rasulova, Dauranbek Arybzhanov, Vladimir Lyubshin, Abdulla Abdikhakimov, Shamsutdin Sagdullaev,Sherzod Nishonov, Gayrat Arifhodjaev,Yuliya Shakirova, Valery Krylov, Marat Khodjibekov
    PJNM. 2016; 6(1): 11-18
    » Abstract

  • Whither Nuclear Medicine Training in Pakistan?
    Durr-e-Sabih
    PJNM. 2016; 6(1): 1-2
    » Abstract

  • Radiosynoviorthesis in pigmented villonodular synovitis using Re-188 labelled tin colloid: a case report
    Aakif U Khan, Hameedullah, Abdul Saeed Shah, Muhammad Rauf Khattak
    PJNM. 2016; 6(1): 42-47
    » Abstract

  • Validation of Ottawa ankle rule utilizing radionuclide skeletal scintigraphy
    Shagufta Zafar Qureshi, Fida Hussain Shah, Mohammad Amin Waqar
    PJNM. 2016; 6(1): 32-41
    » Abstract

  • Unsuspected chronic multifocal osteomyelitis diagnosed on a whole-body 18F-FDG PET/CT scan
    Qaisar Hussain Siraj, Amir Javaid, Khattab Khaled, Anwar Al-Banna
    PJNM. 2016; 6(1): 75-78
    » Abstract

  • Estimation of time for release of patients after the administration of I-131 to thyrotoxicosis patients
    Muhammad Akhtar, Jawad Akhtar Hussain, Akbar Ali, Sheraz Akhtar
    PJNM. 2016; 6(1): 3-10
    » Abstract

  • Assessment of renal parenchymal damage by DMSA after PCNL procedure in children using adult-sized equipment
    Mohammad Sohaib, Manoj U Shenoy, Michael J Kellett, Patrick G Duffy, Isky Gordon
    PJNM. 2016; 6(1): 19-24
    » Abstract

  • Unusual spinal metastases from an adenoid cystic carcinoma of the maxillary sinus seen on a bone scan: a case report
    O Ait Sahel, I Ghfir, H Guerrouj, Y Benameur, N Benraiss
    PJNM. 2016; 6(1): 48-52
    » Abstract

  • SPECT/CT imaging of primary mediastinal goitre: case report and literature review
    Imad Ghfir, Abdallah Achir, Hasnae Guerrouj, Salah Nabih Oueriagli, Omar Ait Sahel, N Benraïs Aouad
    PJNM. 2016; 6(1): 53-58
    » Abstract

  • Vitamin B12 deficiency: prevalence and evaluation of a reversible co-morbidity in hypothyroid patients
    Aniqa Jabeen, Sumaira Mushtaq, Hassan Raza, Mohammd Ali Memon
    PJNM. 2016; 6(1): 25-31
    » Abstract

  • Most Downloaded
  • Unusual spinal metastases from an adenoid cystic carcinoma of the maxillary sinus seen on a bone scan: a case report
    O Ait Sahel, I Ghfir, H Guerrouj, Y Benameur, N Benraiss
    PJNM. 2016; 6(1): 48-52
    » Abstract

  • Lactate dehydrogenase (LDH) as predictive factor of the pain free syndrome duration after radionuclide treatment of bone metastases in patients with breast cancer
    Nigora Rasulova, Dauranbek Arybzhanov, Vladimir Lyubshin, Abdulla Abdikhakimov, Shamsutdin Sagdullaev,Sherzod Nishonov, Gayrat Arifhodjaev,Yuliya Shakirova, Valery Krylov, Marat Khodjibekov
    PJNM. 2016; 6(1): 11-18
    » Abstract

  • Multifocal osteomyelitis on bone scan performed for mandibular mass with uncertain malignancy
    Salah Oueriagli Nabih, Hassna El Guerrouj, Imad Ghfir, Nouzha Ben Raïs
    PJNM. 2016; 6(1): 72-74
    » Abstract

  • Radiosynoviorthesis in pigmented villonodular synovitis using Re-188 labelled tin colloid: a case report
    Aakif U Khan, Hameedullah, Abdul Saeed Shah, Muhammad Rauf Khattak
    PJNM. 2016; 6(1): 42-47
    » Abstract

  • Vitamin B12 deficiency: prevalence and evaluation of a reversible co-morbidity in hypothyroid patients
    Aniqa Jabeen, Sumaira Mushtaq, Hassan Raza, Mohammd Ali Memon
    PJNM. 2016; 6(1): 25-31
    » Abstract

  • Whither Nuclear Medicine Training in Pakistan?
    Durr-e-Sabih
    PJNM. 2016; 6(1): 1-2
    » Abstract

  • SPECT/CT imaging of primary mediastinal goitre: case report and literature review
    Imad Ghfir, Abdallah Achir, Hasnae Guerrouj, Salah Nabih Oueriagli, Omar Ait Sahel, N Benraïs Aouad
    PJNM. 2016; 6(1): 53-58
    » Abstract

  • Unsuspected chronic multifocal osteomyelitis diagnosed on a whole-body 18F-FDG PET/CT scan
    Qaisar Hussain Siraj, Amir Javaid, Khattab Khaled, Anwar Al-Banna
    PJNM. 2016; 6(1): 75-78
    » Abstract

  • Functional ectopic cystic parathyroid adenomas: case reports and literature review
    Nigora Rasulova, Qaisar Hussain Siraj, Amir Javaid, Anwar Al-Banna
    PJNM. 2016; 6(1): 63-68
    » Abstract

  • Validation of Ottawa ankle rule utilizing radionuclide skeletal scintigraphy
    Shagufta Zafar Qureshi, Fida Hussain Shah, Mohammad Amin Waqar
    PJNM. 2016; 6(1): 32-41
    » Abstract

  • Most Cited Articles