Original Article
Pak J Nucl Med. 2018; 8(1): 27-30

The effect of radioactive iodine therapy on urine sterilization in patients with differentiated thyroid cancer

Authors: Atena Aghaee, pooya darmani, ghasemali divband, seyed rasoul Zakavi, sousan shafeie, abbasali zareaati, narjess Ayati.

View PDF DOI: 10.24911/PJNMed.175-1532409254

Abstract

Background: Urinary tract infection is the most common infection which necessitates antibiotics prescription. On the other hand, the appearance of antimicrobial resistance is one of the major health problems due to irrational antibiotic administration. Radio iodine therapy, using I-131 following thyroidectomy, is the standard treatment for the patients with differentiated thyroid cancer (DTC). After the consumption of radioactive iodine, it mainly excretes through the urinary system. This study is aimed to assess the effect of radioactive iodine (I-131) in the eradication of asymptomatic bacteriuria (ABU). Methods: Between September 2015 and May 2017, all the patients with DTC who were hospitalized to Nuclear Medicine Department for radio iodine ablation therapy were enrolled in the study. Urine analysis and culture were done for all the patients before iodine administration. If the result of the urine assessment was positive for the infection, urine culture repeated 1 week later and compare with pre-treatment results. Results: Of 182 patients, 10 cases had abnormal urine culture results. Five patients had CFU under 100,000, therefore was not considered as ABU; however, two of these patients had sterile urine after the treatment. Our only positive case had post treatment sterile urine. Conclusion: Considering radioactive iodine urine excretion, high radiation induced by radioactive iodine that passes through urinary tract may eradicate infection of genitourinary system

Keywords:   Radioiodine therapy, Iodine-131, asymptomatic bacteriuria, urinary tract infection, differentiated thyroid cancer.


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The effect of radioactive iodine therapy on urine sterilization in patients with differentiated thyroid cancer


Authors
Atena Aghaee
Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
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pooya darmani
Mashhad University of Medical Sciences, Mashhad, Iran
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ghasemali divband
Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
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seyed rasoul Zakavi
Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
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sousan shafeie
Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
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abbasali zareaati
Mashhad University of Medical Sciences, Mashhad, Iran
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narjess Ayati
Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
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Correspondence to:
. narjess Ayati, nuclear medicine research center-mashhad University of Medical Sciences; ayatin@mums.ac.ir

Publication history
Received 24 Jul 2018
Revised 23 Feb 2019
Accepted 23 Apr 2019
Published online 08 Oct 2019
Published in print 10 Dec 2019
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How to cite this article

Pubmed Style

Aghaee A, darmani p, divband g, Zakavi sr, shafeie s, zareaati a, Ayati n, . The effect of radioactive iodine therapy on urine sterilization in patients with differentiated thyroid cancer. Pak J Nucl Med. 2018; 8(1): 27-30. doi:10.24911/PJNMed.175-1532409254


Web Style

Aghaee A, darmani p, divband g, Zakavi sr, shafeie s, zareaati a, Ayati n, . The effect of radioactive iodine therapy on urine sterilization in patients with differentiated thyroid cancer. http://www.pjnmed.com/?mno=208 [Access: April 08, 2020]. doi:10.24911/PJNMed.175-1532409254


AMA (American Medical Association) Style

Aghaee A, darmani p, divband g, Zakavi sr, shafeie s, zareaati a, Ayati n, . The effect of radioactive iodine therapy on urine sterilization in patients with differentiated thyroid cancer. Pak J Nucl Med. 2018; 8(1): 27-30. doi:10.24911/PJNMed.175-1532409254


Vancouver/ICMJE Style

Aghaee A, darmani p, divband g, Zakavi sr, shafeie s, zareaati a, Ayati n, . The effect of radioactive iodine therapy on urine sterilization in patients with differentiated thyroid cancer. Pak J Nucl Med. (2018), [cited April 08, 2020]; 8(1): 27-30. doi:10.24911/PJNMed.175-1532409254


Harvard Style

Aghaee, A. ., darmani, p. ., divband, g. ., Zakavi, s. r. ., shafeie, s. ., zareaati, a. ., Ayati, n. . & (2018) The effect of radioactive iodine therapy on urine sterilization in patients with differentiated thyroid cancer. Pak J Nucl Med, 8 (1), 27-30. doi:10.24911/PJNMed.175-1532409254


Turabian Style

Aghaee, Atena , pooya darmani, ghasemali divband, seyed rasoul Zakavi, sousan shafeie, abbasali zareaati, narjess Ayati, and . 2018. The effect of radioactive iodine therapy on urine sterilization in patients with differentiated thyroid cancer. Pakistan Journal of Nuclear Medicine, 8 (1), 27-30. doi:10.24911/PJNMed.175-1532409254


Chicago Style

Aghaee, Atena , pooya darmani, ghasemali divband, seyed rasoul Zakavi, sousan shafeie, abbasali zareaati, narjess Ayati, and . "The effect of radioactive iodine therapy on urine sterilization in patients with differentiated thyroid cancer." Pakistan Journal of Nuclear Medicine 8 (2018), 27-30. doi:10.24911/PJNMed.175-1532409254


MLA (The Modern Language Association) Style

Aghaee, Atena , pooya darmani, ghasemali divband, seyed rasoul Zakavi, sousan shafeie, abbasali zareaati, narjess Ayati, and . "The effect of radioactive iodine therapy on urine sterilization in patients with differentiated thyroid cancer." Pakistan Journal of Nuclear Medicine 8.1 (2018), 27-30. Print. doi:10.24911/PJNMed.175-1532409254


APA (American Psychological Association) Style

Aghaee, A. ., darmani, p. ., divband, g. ., Zakavi, s. r. ., shafeie, s. ., zareaati, a. ., Ayati, n. . & (2018) The effect of radioactive iodine therapy on urine sterilization in patients with differentiated thyroid cancer. Pakistan Journal of Nuclear Medicine, 8 (1), 27-30. doi:10.24911/PJNMed.175-1532409254


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